{"id":1647,"date":"2019-05-14T14:49:35","date_gmt":"2019-05-14T14:49:35","guid":{"rendered":"https:\/\/bxta-staging.website\/bxtaccelyon-addresses-concerns-that-patients-may-be-misled-by-news-of-hdr-brachytherapy-monotreatment\/"},"modified":"2021-09-14T21:34:09","modified_gmt":"2021-09-14T21:34:09","slug":"bxtaccelyon-addresses-concerns-that-patients-may-be-misled-by-news-of-hdr-brachytherapy-monotreatment","status":"publish","type":"post","link":"https:\/\/bxta.com\/es\/bxtaccelyon-addresses-concerns-that-patients-may-be-misled-by-news-of-hdr-brachytherapy-monotreatment\/","title":{"rendered":"BXTAccelyon addresses concerns that patients may be misled by news of HDR brachytherapy monotreatment"},"content":{"rendered":"<div>\n<div>BXTAccelyon has responded to an article on the Daily Mail that claims that a ten-minute shot of High Dose-Rate (HDR) radiation treatment is a \u201csafe and effective\u201d choice for low-risk prostate cancer patients.<\/div>\n<div>The article reports that a three year study of prostate cancer patients from the Christie Hospital in Manchester and Mount Vernon in London claims that a one-hit treatment of HDR brachytherapy cuts the risk of side-effects and reduces the toxic impact of radiotherapy treatment when compared to external-beam radiation therapy (EBRT), which it terms \u2018lower-strength\u2019 radiotherapy.<\/div>\n<div>However, the article both confuses HDR brachytherapy with radiotherapy and fails to refer to alternative findings from clinical data that offer a contrary view on this treatment option, which should be appropriately termed as \u2018single fraction HDR\u2019.<\/div>\n<div>Rather than radiotherapy, which is an external treatment, brachytherapy is an internal treatment delivering radiation to the tumour site. Brachytherapy can be either a permanent implant that delivers low-dose radiation (LDR-B) or a temporary implant that delivers a higher dose over multiple sessions (HDR-B). HDR-B has been trialled as a single session, or fraction, treatment, with clinical data still being assessed.<\/div>\n<div>In contrast to the Christie Hospital &amp; Mount Vernon study, research presented at the largest UK &amp; NI conference of Brachytherapy experts, that convened last month offered a contrary view. Clinical trial data presented by Gerard Morton, Affiliate Scientist, Sunnybrook Health Sciences Centre, Toronto, included research from an independent Spanish study* which indicated that single fraction HDR-B monotherapy produced unacceptable levels of bDFS (Biochemical Disease-Free Survival), at 66% after 5 years compared to significantly higher levels with other established surgical and radiotherapy treatments. bDFS is one of the key measures used to determine the long-term efficacy of radiotherapy treatments.<\/div>\n<div>Morton also presented research which highlighted that this form of HDR treatment is associated with more late urinary symptoms when compared to alternative treatment options, and whilst Toxicity from single fraction is slightly less in the first 12 months, it does get worse beyond 3 years. Moreover, data from Sunnybrook\u2019s own randomised trial indicated that single fraction HDR-B monotherapy (19g) drives the lowest level response to PSA, compared to a 27gr-2 fraction treatment \u2013 meaning that the cancer is not responding as well.<\/div>\n<div>This is borne out by the American Brachytherapy Society, whose consensus guidelines for HDR-B (published in 2012) concluded that different HDR prescription doses all had similar outcomes in terms of toxicity and disease control and therefore \u2018no particular dose fractionation can be recommended\u2019.<\/div>\n<div>There are many treatment options available to prostate cancer patients \u2013 from radical prostatectomy and EBRT, to HDR-B and LDR-B, as well as brachytherapy boosts in combination with EBRT, which allow a highly conformal dose of radiation to be delivered to the prostate in a safe, efficient manner and deliver highly effective, clinically proven results.<\/div>\n<div>Prostate cancer patients \u2013 especially those at early stages of diagnosis \u2013 are in a vulnerable position. The right treatment for any patient is a highly personalised decision and needs to take into consideration both the cancer diagnosis itself as well as a patient\u2019s lifestyle choices. It is therefore the duty of medical professionals, and those publishing \u2018guidance\u2019 in any form, to provide fully considered and informed facts.<\/div>\n<div>ENDS<\/div>\n<div>*Study = \u201cHigh-dose rate interstitial brachy as monotherapy in one fraction\u201d Prada, Cardenal, Blanco et al<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>BXTAccelyon has responded to an article on the Daily Mail that claims that a ten-minute shot of High Dose-Rate (HDR) radiation treatment is a \u201csafe and effective\u201d choice for low-risk prostate cancer patients.The article reports that a three year study of prostate cancer patients from the Christie Hospital in Manchester and Mount Vernon in London claims that a one-hit treatment of HDR brachytherapy cuts the risk of side-effects and reduces the toxic impact of radiotherapy treatment when compared<\/p>","protected":false},"author":10,"featured_media":197,"comment_status":"open","ping_status":"open","sticky":false,"template":"template-old-blog.php","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-1647","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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