{"id":1628,"date":"2020-07-21T11:34:58","date_gmt":"2020-07-21T11:34:58","guid":{"rendered":"https:\/\/bxta-staging.website\/patients-treated-with-low-dose-rate-brachytherapy-boost-therapy-in-combination-with-external-beam-radiotherapy-achieve-more-effective-psa-control\/"},"modified":"2021-09-14T21:33:48","modified_gmt":"2021-09-14T21:33:48","slug":"patients-treated-with-low-dose-rate-brachytherapy-boost-therapy-in-combination-with-external-beam-radiotherapy-achieve-more-effective-psa-control","status":"publish","type":"post","link":"https:\/\/bxta.com\/de\/patients-treated-with-low-dose-rate-brachytherapy-boost-therapy-in-combination-with-external-beam-radiotherapy-achieve-more-effective-psa-control\/","title":{"rendered":"Patienten, die mit Low Dose Rate Brachytherapie-Boost-Therapie in Kombination mit externer Strahlentherapie behandelt werden, erreichen eine effektivere PSA-Kontrolle"},"content":{"rendered":"<div>\n<div>Neue Original-Forschungsergebnisse des Leeds Teaching Hospitals NHS Trust (2019), die im Journal of Clinical and Translational Radiation Oncology von Elsevier ver\u00f6ffentlicht wurden, zeigen, dass M\u00e4nner mit Prostatakrebs im mittleren und hohen Risikobereich, die mit einem Brachytherapie-Boost mit niedriger Dosisrate in Kombination mit externer Strahlentherapie (LDR-EBRT) behandelt wurden, \u00fcber einen Zeitraum von f\u00fcnf Jahren nach der Behandlung eine effektivere Kontrolle \u00fcber ihren PSA-Wert erreichen als M\u00e4nner, die mit einem Brachytherapie-Boost mit hoher Dosisrate (HDR-EBRT) behandelt wurden.<\/div>\n<div>Die Dosiseskalation f\u00fchrt bei lokal begrenztem Prostatakrebs nachweislich zu einem verbesserten biochemischen progressionsfreien \u00dcberleben (bPFS) bzw. einer besseren Kontrolle des PSA-Werts. Die Steigerung der Dosis kann auf verschiedene Weise erfolgen: durch externe Strahlentherapie (EBRT) allein, durch Brachytherapie und durch eine Kombination beider Therapien. Mehrere Studien an Patienten mit intermedi\u00e4rem und Hochrisiko-Prostatakrebs haben \u00fcber ein verbessertes bPFS sowohl f\u00fcr die Hochdosis-Brachytherapie in Kombination mit EBRT (HDR-EBRT) als auch f\u00fcr die permanente Seed-Brachytherapie mit niedriger Dosisrate in Kombination mit EBRT (LDR-EBRT) im Vergleich zur EBRT allein berichtet. Allerdings fehlt es an Evidenz, die LDR-EBRT direkt mit HDR-EBRT vergleicht.<\/div>\n<div>Die Leeds-Studie verglich die Ergebnisse von 116 M\u00e4nnern, die mit LDR-EBRT behandelt wurden, und von 171 M\u00e4nnern, die mit HDR-EBRT therapiert wurden, \u00fcber die Zeitr\u00e4ume 1996 bis 2007 bzw. 2007 bis 2012. Die Studie ergab, dass die Wahrscheinlichkeit einer biochemischen Progression, also eines erh\u00f6hten PSA-Wertes, bei den mit HDR-EBRT behandelten Patienten mehr als doppelt so hoch war als bei LDR-EBRT-Patienten, was bedeutet, dass mit LDR-EBRT therapierte Patienten eine h\u00f6here Wahrscheinlichkeit f\u00fcr eine bessere Krankheitskontrolle hatten.<\/div>\n<div>PSA ist ein wichtiger Pr\u00e4diktor f\u00fcr das langfristige bPFS bei M\u00e4nnern, die auf Prostatakrebs behandelt werden, und ein niedriger PSA-Wert ist mit einem besseren Ergebnis verbunden.<\/div>\n<div>Mit der Zunahme von diagnostiziertem Prostatakrebs und den bedeutenden Investitionen in Diagnostik und Therapie des Prostatakarzinoms ist es wichtiger als je zuvor, dass betroffene M\u00e4nner alle verf\u00fcgbaren Behandlungsoptionen sowie die Gesamt- und progressionsfreien \u00dcberlebensraten recherchieren und diesbez\u00fcglich Rat suchen.<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>New original research from Leeds Teaching Hospitals NHS Trust, as published in Elsevier\u2019s Journal of Clinical and Translational Radiation Oncology, has revealed that men with intermediate- and high-risk prostate cancer treated with a low dose rate brachytherapy boost in combination with external beam radiotherapy (LDR-EBRT) achieve more effective PSA control over a five year post-treatment period than men treated with a high dose rate brachytherapy boost (HDR-EBRT).Dose escalation has been shown<\/p>","protected":false},"author":10,"featured_media":1045,"comment_status":"open","ping_status":"open","sticky":false,"template":"template-old-blog.php","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[7],"tags":[],"class_list":["post-1628","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-resources"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - 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